Hydrochloric Acid → HCID 12761772、化合物

HRID 1447028ノート

反応式

HRID 1447028 の反応式
[ClH:1].[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(OCC)C>CO>[ClH:1].[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 127617712-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-(phenylmethyl)-1H-imidazole

生成物 1

HCID 12761772HCID 12761772、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Excess 3% hydrogen chloride in methanol is added to a solution of 1.0 g 1-benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole in 20 ml methanol. Diethyl ether is added until precipitation is complete. The product is filtered, washed with ether, air dried and recrystallized from methanol/acetone to yield 1-benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole hydrochloride, m.p. 105°-107° C.(d).

後処理

  1. filtrationThe product is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized from methanol/acetone

出典と根拠

ORDレコード
ord-6504e158555346cca1b426f81d6d0f2a
出典データセット
uspto-grants-1982_02
特許番号
US04315021

反応ノート

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