Potassium Carbonate → 2-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-(phenylmethyl)-1H-imidazole

HRID 1447029ノート

反応式

HRID 1447029 の反応式
Cl.[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH2:2]([N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[CH2:14][CH:15]1[O:20][C:19]2[CH:21]=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 12761772HCID 12761772、化合物

生成物 1

HCID 127617712-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-(phenylmethyl)-1H-imidazole

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

1-Benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole hydrochloride (1.0 g) suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 1-benzyl-2-(1,4-benzodioxan-2-ylmethyl)imidazole.

後処理

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-98be6c1b3304495fa9b0c0fe1730be3a
出典データセット
uspto-grants-1982_02
特許番号
US04315021

反応ノート

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