1,2,3,4-Tetrahydroisoquinoline → 2-Acetyl-1,2,3,4-tetrahydroisoquinoline

HRID 1447110ノート

反応式

HRID 1447110 の反応式
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1)(=[O:13])[CH3:12]

参加物

3

反応物 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 7918Acetic Anhydride

生成物 1

HCID 6002152-Acetyl-1,2,3,4-tetrahydroisoquinoline

実験手順

A mixture of 100 g. (0.75 mole) 1,2,3,4-tetrahydroisoquinoline and 150 ml. acetic anhydride was stirred at ambient temperature for 24 hours and then concentrated to dryness at reduced pressure. The residual liquid was dissolved in methylene chloride and solid potassium carbonate was added to neutralize the solution. The excess potassium carbonate was removed by filtration and the filtrate was concentrated to dryness at reduced pressure to afford 2-acetyl-1,2,3,4-tetrahydroisoquinoline as a yellow liquid.

後処理

  1. additionA mixture of 100 g
  2. concentrationconcentrated to dryness at reduced pressure
  3. dissolutionThe residual liquid was dissolved in methylene chloride
  4. additionsolid potassium carbonate was added
  5. customThe excess potassium carbonate was removed by filtration
  6. concentrationthe filtrate was concentrated to dryness at reduced pressure

出典と根拠

ORDレコード
ord-c79b68032fbe4b7eb3ea1a3bcdf03850
出典データセット
uspto-grants-1982_02
特許番号
US04315935

反応ノート

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