Acetic Acid → 1-(2-nitrobenzyl)-1H-pyrrole
反応式
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])([O-:3])=[O:2].CO[CH:14]1[CH2:18][CH2:17][CH:16](OC)O1.C(O)(=O)C>O>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][N:7]1[CH:14]=[CH:18][CH:17]=[CH:16]1)([O-:3])=[O:2]参加物
5
実験手順
The starting material is prepared as follows: The mixture of 3,078 g of o-nitrobenzylamine and 2,670 g of 2,5-dimethoxytetrahydrofuran is added rapidly to 10,000 ml of glacial acetic acid at 86° while stirring under nitrogen. The mixture is stirred at 95° for 1.25 hours, cooled to 25° and combined with 30,000 ml of water. It is extracted with ethyl acetate, the extract is washed with 10% aqueous sodium hydroxide and 10% aqueous sodium chloride, filtered and evaporated to yield the 1-(o-nitrobenzyl)-pyrrole.
後処理
- customThe starting material is prepared
- stirringThe mixture is stirred at 95° for 1.25 hours
- temperaturecooled to 25°
- extractionIt is extracted with ethyl acetate
- washthe extract is washed with 10% aqueous sodium hydroxide and 10% aqueous sodium chloride
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-e992fb8e8999490195b0aaaf80f95508
- 出典データセット
- uspto-grants-1982_02
- 特許番号
- US04316900
反応ノート
読み込み中…