Hydrochloric Acid → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

HRID 1447859ノート

反応式

HRID 1447859 の反応式
[Na+].[F:2][C:3]([F:23])([F:22])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([O-:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1.Cl>C(Cl)Cl>[F:22][C:3]([F:2])([F:23])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:15]3[N:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[C:14]3[N:13]=[CH:12][CH:11]=2)[CH:5]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 705907417-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

生成物 1

HCID 103353477-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 0.70 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt, 25 ml. of methylene chloride and 10 ml. of 1 N hydrochloric acid is stirred overnight. The solid which forms is collected by filtration. The filtrate is evaporated to produce more solid. The solids are combined and recrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

後処理

  1. additionA mixture of 0.70 g
  2. filtrationThe solid which forms is collected by filtration
  3. customThe filtrate is evaporated
  4. customto produce more solid
  5. customrecrystallized from methylene chloride giving the desired product, m.p. 248°-250° C.

出典と根拠

ORDレコード
ord-b271db2ed96b4fb7b418664539371e6e
出典データセット
uspto-grants-1979_12
特許番号
US04178449

反応ノート

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