Dimethylformamide dimethyl acetal → 3-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one

HRID 1447861ノート

反応式

HRID 1447861 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:11])[CH3:10].CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>>[CH3:16][N:17]([CH3:19])[CH:18]=[CH:10][C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:12])([F:13])[F:1])=[O:11]

参加物

3

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 870952'-(Trifluoromethyl)acetophenone

生成物 1

HCID 542598323-(Dimethylamino)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one

実験手順

A mixture of 35 g. of o-trifluoromethylacetophenone in 35 ml. of dimethylformamide dimethylacetal is refluxed for 8 hours under anhydrous conditions and then evaporated to a yellow oil. Bulb to bulb distillation gives the desired product as a thick yellow oil.

後処理

  1. additionA mixture of 35 g
  2. customevaporated to a yellow oil
  3. distillationBulb to bulb distillation

出典と根拠

ORDレコード
ord-b31ea636f6bc4460bfddb9389ddaf273
出典データセット
uspto-grants-1979_12
特許番号
US04178449

反応ノート

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