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3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone → 6-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone | HCID 54529942 | — |
| 反応物 | HCID 178510443 | HCID 178510443 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 6-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 19756208 | — |
反応手順
A mixture of 1.08 g. of 3-aminopyrazole-4-carbonitrile, 25 ml. of glacial acetic acid and 2.57 g. of 3-dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone is refluxed for 8 hours and then evaporated to a crystalline solid. A methylene chloride solution of this solid is treated as described in Example 1, giving the desired product, m.p. 191°-193° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04178449 |
| 出典データセット | uspto-grants-1979_12 |
| ORD ID | ord-d36622dee21345ab96123d5fa9233aea |
| 出典メモ | uspto-grants-1979_12 |