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Pyrazole, 3-amino-4-cyano-5-ethyl- → 2-Ethyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrazole, 3-amino-4-cyano-5-ethyl- | HCID 114021 | — |
| 反応物 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Ethyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 23329837 | — |
反応手順
A mixture of 7.29 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone and 4.08 g. of 3-amino-5-ethylpyrazole-4-carbonitrile in 25 ml. of glacial acetic acid is refluxed for 15 hours and then evaporated to a residue. This residue is treated as described in Example 1, giving the desired product, m.p. 144°-146° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04178449 |
| 出典データセット | uspto-grants-1979_12 |
| ORD ID | ord-c7d2a74a81d74368a73111bfd738e115 |
| 出典メモ | uspto-grants-1979_12 |