Pyrazole, 3-amino-4-cyano-5-ethyl- → 2-Ethyl-6-methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 1447872

反応式

HRID 1447872 の反応式
C[N:2]([CH3:18])[CH:3]=[C:4]([CH3:17])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:19][C:20]1[C:24](C#N)=[C:23]([CH2:27][CH3:28])[NH:22][N:21]=1>C(O)(=O)C>[CH2:27]([C:23]1[C:24]([C:20]#[N:19])=[C:18]2[N:2]=[CH:3][C:4]([CH3:17])=[C:5]([C:7]3[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=3)[N:21]2[N:22]=1)[CH3:28]

参加物

4

反応物 2

HCID 114021Pyrazole, 3-amino-4-cyano-5-ethyl-HCID 545299423-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

生成物 1

HCID 233298432-Ethyl-6-methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 2.52 g. of 3-dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone and 1.36 g. of 3-amino-5-ethylpyrazole-4-carbonitrile in 25 ml. of glacial acetic acid is refluxed for 15 hours and then evaporated to a residue. The residue is treated as described in Example 1, giving the desired product, m.p. 163°-164° C.

後処理

  1. additionA mixture of 2.52 g
  2. customevaporated to a residue
  3. additionThe residue is treated

出典と根拠

ORDレコード
ord-7e5255c0fcb5487c9166a54136e7e1fb
出典データセット
uspto-grants-1979_12
特許番号
US04178449

関連ノート

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