Acetic Acid → HCID 23329856、化合物

反応式

C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]1[N:20]=[CH:21][NH:22][C:23]=1C#N.[C:26](O)(=O)C>>[CH3:26][C:3]1[CH:4]=[C:5]([C:7]2[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=2)[N:20]2[CH:21]=[N:22][C:23]([C:19]#[N:18])=[C:17]2[N:2]=1

参加物

反応物 3

HCID 176Acetic Acid

HCID 787775-amino-1H-imidazole-4-carbonitrile

HCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenone

生成物 1

HCID 23329856HCID 23329856、化合物

実験手順

A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 0.01 mole of 4-amino-5-imidazolecarbonitrile is refluxed for 5 hours. The solvent is removed under reduced pressure and the residue worked up as for Example 29 to give the product of the example.