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3-amino-1H-pyrazole-4,5-dicarbonitrile → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-amino-1H-pyrazole-4,5-dicarbonitrile | HCID 338830 | — |
| 反応物 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile | HCID 11370400 | — |
反応手順
A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is treated with trifluoroacetic anhydride to give the product of the example. cl EXAMPLE 44
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04178449 |
| 出典データセット | uspto-grants-1979_12 |
| ORD ID | ord-3be5e32ab22c44608da2087ba1faac10 |
| 出典メモ | uspto-grants-1979_12 |