Sodium Cyanide → 3-Fluoro-4-methoxyphenylacetonitrile

HRID 1447930

反応式

HRID 1447930 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([F:11])[CH:4]=1.[CH2:12]([N:18](CCCCCC)CCCCCC)CCCCC.[C-]#N.[Na+]>O>[F:11][C:5]1[CH:4]=[C:3]([CH2:2][C:12]#[N:18])[CH:8]=[CH:7][C:6]=1[O:9][CH3:10]

参加物

5

反応物 3

HCID 8929Sodium CyanideHCID 66022TrihexylamineHCID 27745534-(Bromomethyl)-2-fluoro-1-methoxybenzene

生成物 1

HCID 1362513-Fluoro-4-methoxyphenylacetonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.

後処理

  1. temperatureis heated at 60°-65° C. for 18 hours
  2. temperatureThe mixture is cooled
  3. extractionextracted in its ether
  4. washwashed with water, saturated sodium chloride solution
  5. dry with materialdried (CNa2SO4)
  6. customEvaporation of the solvent
  7. customgives a solid, (33.2 g)

出典と根拠

ORDレコード
ord-0774a4ac458a4713bcbe32312b9f326f
出典データセット
uspto-grants-1979_12
特許番号
US04178460

関連ノート

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