Sodium Cyanide → 3-Fluoro-4-methoxyphenylacetonitrile
反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([F:11])[CH:4]=1.[CH2:12]([N:18](CCCCCC)CCCCCC)CCCCC.[C-]#N.[Na+]>O>[F:11][C:5]1[CH:4]=[C:3]([CH2:2][C:12]#[N:18])[CH:8]=[CH:7][C:6]=1[O:9][CH3:10]参加物
5
実験手順
A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.
後処理
- temperatureis heated at 60°-65° C. for 18 hours
- temperatureThe mixture is cooled
- extractionextracted in its ether
- washwashed with water, saturated sodium chloride solution
- dry with materialdried (CNa2SO4)
- customEvaporation of the solvent
- customgives a solid, (33.2 g)
出典と根拠
- ORDレコード
- ord-0774a4ac458a4713bcbe32312b9f326f
- 出典データセット
- uspto-grants-1979_12
- 特許番号
- US04178460
反応ノート
読み込み中…