Hydrochloric Acid → p-(2,4-Dimethoxybenzyloxy)phenyl hydrazine hydrochloride

反応式

[CH3:1][O:2][C:3]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:4]=1[CH2:5][O:6][C:7]1[CH:13]=[CH:12][C:10]([NH2:11])=[CH:9][CH:8]=1.[N:20]([O-])=O.[Na+].[ClH:24]>O>[ClH:24].[CH3:1][O:2][C:3]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:4]=1[CH2:5][O:6][C:7]1[CH:13]=[CH:12][C:10]([NH:11][NH2:20])=[CH:9][CH:8]=1

参加物

実験手順

p-(2,4-Dimethoxybenzyloxy)aniline (2.5 g, 0.01 M) is diazotized with concentrated hydrochloric acid (6 ml) and sodium nitrite (1 g) in water (2 ml) at 0° C. This solution is treated with stannous chloride dihydrate (7 g) in concentrated hydrochloric acid (20 ml) at 0° C. for 2 hours. After 12 hours at 0° C. the precipitate is filtered off and recrystallized from ethanol to afford p-(2,4-dimethoxybenzyloxy)phenyl hydrazine hydrochloride. The free base is liberated by treatment with aqueous sodium carbonate and extraction into chloroform.