Hydrochloric Acid → 2-Methylbenzophenone

HRID 1448612

反応式

HRID 1448612 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].O.Cl.[C:16]1([CH3:22])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:22][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:8]

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 1140TolueneHCID 7412Benzoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 672302-Methylbenzophenone収率 93%

実験手順

To a mechanically stirred solution of 1000 grams (7.12 moles) of benzoyl chloride in 6000 grams of toluene was added 1000 grams (7.50 moles) of anhydrous aluminum chloride over a 20-30 minute period. The temperature of the reaction mixture rose to near the boiling point during the addition, and heating at reflux was maintained for three additional hours. After cooling, 1200 milliliters of water were added, slowly at first, followed by 1000 milliliters of concentrated hydrochloric acid. The organic layer was separated, washed twice with hot water and concentrated on a rotary evaporator. Vacuum distillation of the residual oil provided 1300 grams (93% yield) of white, semi-solid methyl benzophenone; (b.p. 180°-200° C., 10-15 mm Hg; m.p. 50° C.) . The infrared spectrum revealed a carbonyl band at 1665 cm-.

後処理

  1. additionThe temperature of the reaction mixture rose to near the boiling point during the addition
  2. temperatureheating
  3. temperatureat reflux
  4. temperaturewas maintained for three additional hours
  5. temperatureAfter cooling
  6. customThe organic layer was separated
  7. washwashed twice with hot water
  8. concentrationconcentrated on a rotary evaporator
  9. distillationVacuum distillation of the residual oil

出典と根拠

ORDレコード
ord-0f1d749c778541f0acb90e51055eabfd
出典データセット
uspto-grants-1979_12
特許番号
US04180674

関連ノート

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