Hydrochloric Acid → 7,8-Diamino-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one

関与物質

反応手順

7-Amino-3-(4-chlorophenyl)-2-isopropyl-8-nitro-chromen-4-one (450 mg, 0.94 mmol) is suspended in methanol (5 ml). Concentrated hydrochloric acid (5 ml) is added. The mixture is placed under an atmosphere of argon, and 10% palladium on activated carbon (50 mg) is added. The reaction mixture is placed under an atmosphere of hydrogen and stirred at room temperature for 24 h. The mixture is filtered through a Celite pad, and the Celite pad is washed with methanol (3×30 ml). The filtrate and the washings are combined and evaporated to give a yellow solid.

情報源と証拠