Sodium Bicarbonate → 6-Methyl-6-hepten-2-one

HRID 1448933ノート

反応式

HRID 1448933 の反応式
C1CO[C:3]([CH3:10])([CH2:4][CH2:5][CH2:6][C:7]([CH3:9])=[CH2:8])[O:2]1.C(=O)(O)[O-].[Na+]>CC(C)=O.Cl>[CH3:9][C:7]([CH2:6][CH2:5][CH2:4][C:3](=[O:2])[CH3:10])=[CH2:8]

参加物

5

反応物 2

HCID 516892Sodium BicarbonateHCID 10975921HCID 10975921、化合物

生成物 1

HCID 1515096-Methyl-6-hepten-2-one収率 70.8%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 6,6-ethylenedioxy-2-methyl-hept-1-ene (12.2 g) in acetone (300 ml) and 10% hydrochloric acid (12 ml) is stirred at room temperature for 1.5 hours. The reaction is neutralized to pH 7 with a sodium bicarbonate solution and the resulting solids are filtered. The acetone is removed in vacuo and the residue is partitioned between ether and brine. The ether extract is dried (Na2SO4) and evaporated in vacuo to give 2-methyl-6-oxo-hept-1-ene as a pale yellow liquid (6.4 g), nmr (CDCl3,δ) 1.7 (br, s, CH3 --C=), 2.12 (s, CH3C=O), 2.4 (t, J=6 Hz, CH2C=O), 4.69 (br, s, 2H, H2C=C).

後処理

  1. filtrationthe resulting solids are filtered
  2. customThe acetone is removed in vacuo
  3. customthe residue is partitioned between ether and brine
  4. extractionThe ether extract
  5. dry with materialis dried (Na2SO4)
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-9b42fc51efac4be69dd93e72bd6f11ad
出典データセット
uspto-grants-1980_02
特許番号
US04188328

反応ノート

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