Water → HCID 13507961、化合物

HRID 1448985ノート

反応式

HRID 1448985 の反応式
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)O)=O)=[CH:5][CH:4]=1.[NH2:25][C:26]([NH2:28])=[S:27].O>CN(C)C=O>[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:25][C:26](=[S:27])[NH:28][C:11]=2[C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 962WaterHCID 2723790ThioureaHCID 15044210HCID 15044210、化合物

生成物 1

HCID 13507961HCID 13507961、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4,4'-di(trifluoromethyl)benzoin (50 g, 0.15 mol) and thiourea (15.2 g, 0.2 mol) in dimethylformamide (350 ml) was refluxed under argon for three hours. The cooled solution was poured into 1 liter of water and the resulting solid was collected, washed with water, air-dried and recrystallized from ethanol to give 4,5-bis-(4-trifluoromethylphenyl)-1H-imidazole-2-thione, m.p. 312°-315°.

後処理

  1. temperaturewas refluxed under argon for three hours
  2. customthe resulting solid was collected
  3. washwashed with water
  4. customair-dried
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-a63b6b8564dc4b17bfcc1c173d3330ab
出典データセット
uspto-grants-1980_02
特許番号
US04188397

反応ノート

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