3-Nitrobenzaldehyde → 2-Acetoxymethyl-6-methyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

HRID 1449001ノート

反応式

HRID 1449001 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O)([O-:3])=[O:2].[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]([CH2:19][O:20][C:21](=[O:23])[CH3:22])=O)[CH3:13].[CH2:25]([O:27][C:28](=[O:33])/[CH:29]=[C:30](\[NH2:32])/[CH3:31])[CH3:26]>C(O)C>[CH2:12]([O:14][C:15]([C:16]1[CH:7]([C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[C:29]([C:28]([O:27][CH2:25][CH3:26])=[O:33])=[C:30]([CH3:31])[NH:32][C:17]=1[CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:24])[CH3:13]

参加物

5

反応物 3

HCID 74493-NitrobenzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 11480907Ethyl 4-acetoxyacetoacetate

生成物 1

HCID 133883462-Acetoxymethyl-6-methyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

7.5 g of 3-nitrobenzaldehyde, 9.4 g of γ-acetoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol are heated under reflux for 20 hours, the mixture is cooled and the precipitate is filtered off.

後処理

  1. temperatureunder reflux for 20 hours
  2. temperaturethe mixture is cooled
  3. filtrationthe precipitate is filtered off

出典と根拠

ORDレコード
ord-6fecc888405549d1a07bffdb9dc092f3
出典データセット
uspto-grants-1980_02
特許番号
US04188395

反応ノート

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