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Ethanol → 2-Phthalimidomethyl-6-methyl-4-pyridyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-Pyridinecarboxaldehyde | HCID 14273 | — |
| 反応物 | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| 反応物 | Ethyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoate | HCID 701239 | — |
| 生成物 | 2-Phthalimidomethyl-6-methyl-4-pyridyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70591778 | 75% |
反応手順
A solution of 4.7 ccs of pyridine-2-aldehyde, 12.4 g of phthalimidoacetoacetic acid ethyl ester and 5.85 g of β-aminocrotonic acid ethyl ester in 100 ccs of ethanol is heated under reflux for 24 hours and, after cooling and filtering, crystals (beige) of melting point 156°-158° C. are obtained, yield: 75%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04188395 |
| 出典データセット | uspto-grants-1980_02 |
| ORD ID | ord-7a40f5b2a7284e68b6010bd61890c6d8 |
| 出典メモ | uspto-grants-1980_02 |