関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | O-Phenylenediamine | HCID 7243 | — |
| 反応物 | Benzonitrile, 3-ethyl- | HCID 96692 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(m-Ethylphenyl)benzimidazole | HCID 20347799 | — |
反応手順
2.2 g. of o-phenylenediamine and 3.1 g. of m-ethylbenzonitrile were dissolved in 30 ml. of methanol. To the solution was added 1.1 g. of sodium methoxide in methanol. The mixture was stirred at 60° C. for 2 hours, acidified with acetic acid, stirred again at 100° C. for additional 3 hours and poured in 100 ml. of water. The resulting crystals were filtered off, dried and recrystallized from ethyl acetate. 2.7 g. of the product (60% of theory) was obtained. The product was identical to that obtained in Example 23.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04188486 |
|---|
| 出典データセット | uspto-grants-1980_02 |
|---|
| ORD ID | ord-9a49a61c1298479496cbdb29f4b4d733 |
|---|
| 出典メモ | uspto-grants-1980_02 |
|---|
