Glycidol → N-(2,3-dihydroxypropyl)-N-(2-hydroxyoctyl) amine

HRID 1449173

反応式

HRID 1449173 の反応式
[OH:1][CH:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][NH2:4].[CH2:11]1[O:13][CH:12]1[CH2:14][OH:15]>C1(C)C=CC=CC=1>[OH:13][CH:12]([CH2:14][OH:15])[CH2:11][NH:4][CH2:3][CH:2]([OH:1])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

参加物

4

反応物 2

HCID 11164GlycidolHCID 3450531-Aminooctan-2-ol

生成物 1

HCID 54553438N-(2,3-dihydroxypropyl)-N-(2-hydroxyoctyl) amine収率 90.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

108.8 grams of 2-hydroxyoctyl amine were dissolved in 500 ml of toluene, heated to reflux, treated within 10 minutes under stirring with 18.5 grams of glycidol and held at reflux for 2 hours. Subsequently, the solvent was drawn off and the excess amine distilled off in a vacuum. There were obtained as a residue 49.5 grams (90.5% of theory) of N-(2,3-dihydroxypropyl)-N-(2-hydroxyoctyl) amine which after recrystallization from ethylacetate gave colorless crystals having a melting point of 85°-90° C.

後処理

  1. temperatureheated
  2. temperatureto reflux
  3. additiontreated within 10 minutes
  4. temperatureat reflux for 2 hours
  5. distillationthe excess amine distilled off in a vacuum

出典と根拠

ORDレコード
ord-3cc21826ad4b418a9bf8b294e6c05baf
出典データセット
uspto-grants-1980_02
特許番号
US04189550

関連ノート

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