Sulfuric Acid → Ibuprofen, (+-)-

HRID 1449227

反応式

HRID 1449227 の反応式
[O-:1][C:2]([CH:4]([C:6]1[CH:15]=[CH:14][C:9]([CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:8][CH:7]=1)[CH3:5])=[O:3].[Na+].S(=O)(=O)(O)O.[Cl-].[Na+]>>[OH:3][C:2]([CH:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][CH:11]([CH3:12])[CH3:13])=[CH:14][CH:15]=1)[CH3:5])=[O:1]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 5234Sodium ChlorideHCID 5338317Ibuprofen, Sodium Salt

生成物 1

HCID 3672Ibuprofen, (+-)-収率 93.2%

実験手順

The aqueous basic fraction containing sodium ibuprofen salt was acidified with 6N sulfuric acid, sodium chloride was added, and then extracted twice with Skellysolve B to take up the ibuprofen acid product therein. The Skellysolve B phase was dried over sodium sulfate and evaporated to leave as residue 867.7 mg. (93.2 percent yield) of ibuprofen which was 99.9 percent pure by gas liquid chromatographic (GLC) analysis.

後処理

  1. additionwas added
  2. extractionextracted twice with Skellysolve B
  3. dry with materialThe Skellysolve B phase was dried over sodium sulfate
  4. customevaporated
  5. customto leave as residue 867.7 mg

出典と根拠

ORDレコード
ord-9fb0f63a25da4ea98b6394c83ae0b917
出典データセット
uspto-grants-1980_02
特許番号
US04189596

関連ノート

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