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Pyrrole → 2,2'-(2,2,3,3,4,4,4-Heptafluorobutane-1,1-diyl)di(1H-pyrrole)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrole | HCID 8027 | — |
| 反応物 | Heptafluorobutyraldehyde | HCID 67809 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2,2'-(2,2,3,3,4,4,4-Heptafluorobutane-1,1-diyl)di(1H-pyrrole) | HCID 10470855 | — |
反応手順
Pyrrole (2; 50 mmol) and heptafluorobutyraldehyde (7; R=CF3CF2, as the hydrate, 25 mmol ) were condensed in tetrahydrofuran in the presence of acid catalyst as described above to give bis-(pyrrol-2-yl) hepta-fluoroprop-1-ylmethane (8; R=CF3CF2) in >50% isolated yield. GCMS m/z; 314 (M+, 22%), 145 (100%); 1H NMR (δ, CDCl3 at 7.24); 4.92 (t, 1H), 6.22 (d, 4H), 6.75 (s, 2H), 8.07 (bs, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05599948 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-7a25a68543d4452eb6ce97607089cb09 |
| 出典メモ | uspto-grants-1997_02 |