Sulfuric Acid → 3-Bromo-4-chloro-5-fluoro-2-picoline

HRID 1450066

反応式

HRID 1450066 の反応式
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]([CH3:9])[CH:3]=1.[Br:10]Br.S(=O)(=O)(O)O>>[Br:10][C:3]1[C:4]([CH3:9])=[N:5][CH:6]=[C:7]([F:8])[C:2]=1[Cl:1]

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 24408BromineHCID 196914104-Chloro-5-fluoro-2-methylpyridine2 回

生成物 1

HCID 196914363-Bromo-4-chloro-5-fluoro-2-picoline

実験手順

4-Chloro-5-fluoro-2-picoline, the product of Example 66, is treated with bromine in fuming sulfuric acid containing 65% sulfur trioxide for 7 hours at 80° C. as described by L. van der Does and H. J. Hertog in Rec Trav Chim 81:864 (1965) to afford the title compound.

後処理

  1. customfor 7 hours
  2. customat 80° C.

出典と根拠

ORDレコード
ord-50b7ea4af53a4eae90f99f37b3400dbd
出典データセット
uspto-grants-1997_02
特許番号
US05599816

関連ノート

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