化工社化工社 化学情報印刷レポート · 研究参考用
2,5-Dichloronitrobenzene → 2-Chlorodibenz(b,f)-1,4-oxazepin-11(10H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dichloronitrobenzene | HCID 6977 | — |
| 反応物 | Potassium salicylaldehyde | HCID 86750311 | — |
| 生成物 | 2-Chlorodibenz(b,f)-1,4-oxazepin-11(10H)-one | HCID 76619 | — |
反応手順
The starting material 8-chloro-10,11-dihydro-dibenz[b,f][1,4]oxazepin-11-one was prepared according to the procedures reported in Coyne et al (J. Med. Chem., 1967, 10:541). Briefly, this entailed coupling potassium salicylaldehyde with 2,5-dichloronitrobenzene, followed by oxidation to carboxylic acid, reduction of nitro, and finally ring closure, to yield the desired 8-chloro starting material.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05602120 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-e19f0043f5184b1b8ea158f02f942967 |
| 出典メモ | uspto-grants-1997_02 |