2-(4-Aminophenyl)benzonitrile → 7-[(2'-Cyanobiphenyl-4-yl)amino]-5-ethylpyrazolo[1,5-a]pyrimidine

HRID 1450403ノート

反応式

HRID 1450403 の反応式
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH2:11][CH3:12])[CH:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]#[N:27])=[CH:16][CH:15]=1>C(O)C>[C:26]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:2]2[N:7]3[N:8]=[CH:9][CH:10]=[C:6]3[N:5]=[C:4]([CH2:11][CH3:12])[CH:3]=2)=[CH:19][CH:18]=1)#[N:27]

参加物

4

反応物 2

HCID 13939262-(4-Aminophenyl)benzonitrileHCID 105354107-Chloro-5-ethylpyrazolo[1,5-a]pyrimidine

生成物 1

HCID 199759777-[(2'-Cyanobiphenyl-4-yl)amino]-5-ethylpyrazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.4 g (7.7 mmol) of the chloride from Example 1, Step B and 1.5 g (7.7 mmol) 4-Amino-2'-cyanobiphenyl were heated in 30 ml dry ethanol for 5 h. After removal of the solvent in vacuo the nitrile was obtained in colorless crystals from ethanol,

後処理

  1. customAfter removal of the solvent in vacuo the nitrile
  2. customwas obtained in colorless crystals from ethanol

出典と根拠

ORDレコード
ord-9d9b46476e6e49ad8be937f6ba4ba0f3
出典データセット
uspto-grants-1997_02
特許番号
US05602136

反応ノート

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