Malonic Acid → 3-Amino-3-(pyridin-3-yl)propanoic acid
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[C:9]([O-:12])(=[O:11])[CH3:10].[NH4+:13].C(O)(=O)CC(O)=O>CC(O)C>[NH2:13][CH:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[CH2:10][C:9]([OH:12])=[O:11]参加物
5
実験手順
To 300 ml of 3-pyridine carboxaldehyde in 3 liters of 2-propanol was added 297 g of ammonium acetate followed by 398 g of malonic acid. The reaction mixture was stirred at reflux for 5 hours. The precipitate was filtered while hot and washed with 2 liters of hot isopropanol. The resulting white solid was then dried to yield 220 g of DL-3-amino-3-(3pyridyl)propionic acid as a white solid.
後処理
- temperatureat reflux for 5 hours
- filtrationThe precipitate was filtered while hot and
- washwashed with 2 liters of hot isopropanol
- customThe resulting white solid was then dried
出典と根拠
- ORDレコード
- ord-a8e099d86cbd4ac497632f86c5117a89
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05602155
反応ノート
読み込み中…