Ammonia → 2-(4-Chlorophenyl)-1-(4-fluoro-2-hydroxy-phenyl)-ethanone

HRID 14505

反応式

HRID 14505 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](Cl)=[O:10])=[CH:4][CH:3]=1.[Al+3].[Cl-].[Cl-].[Cl-].[F:16][C:17]1[CH:18]=[C:19]([OH:23])[CH:20]=[CH:21][CH:22]=1.N>ClCCCl.C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:20]2[CH:21]=[CH:22][C:17]([F:16])=[CH:18][C:19]=2[OH:23])=[O:10])=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 222AmmoniaHCID 97433-FluorophenolHCID 906924-Chlorophenylacetyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 687025202-(4-Chlorophenyl)-1-(4-fluoro-2-hydroxy-phenyl)-ethanone

試薬・触媒・溶媒 2

HCID 111,2-Dichloroethane溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 4-chlorophenylacetyl chloride (27.6 g, 0.15 mol) in 1,2-dichloroethane (200 ml), cooled to 0° C. in an ice bath, under nitrogen is added slowly AlCl3 (21.8 g, 0.16 mol). The reaction mixture is stirred at 0° C. for 20 min. 3-fluorophenol (12.2 g, 0.11 mol) is added, and the reaction mixture is allowed to warm to room temperature, then heated at 90° C. for 16 h. The reaction mixture is cooled to room temperature, then poured cautiously into aqueous ammonia solution (500 ml) with vigourous stirring. The mixture is diluted with CH2Cl2 (250 ml) and filtered through Celite. The organic phase is separated, washed with water, brine and dried (MgSO4). The solvent is removed in vacuo, and the crude product is purified by flash chromatography on silica gel using iso-hexane:ethyl acetate (10:1 to 4:1) as the eluent to give the title compound.

後処理

  1. temperatureto warm to room temperature
  2. temperatureheated at 90° C. for 16 h
  3. temperatureThe reaction mixture is cooled to room temperature
  4. filtrationfiltered through Celite
  5. customThe organic phase is separated
  6. washwashed with water, brine
  7. dry with materialdried (MgSO4)
  8. customThe solvent is removed in vacuo
  9. customthe crude product is purified by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-44e1dcc8469d4abfa6010145fe0f0cf5
出典データセット
uspto-grants-2010_06
特許番号
US07732435B2

関連ノート

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