Water → N-Chloro-4-methoxybenzamide

HRID 1450640ノート

反応式

HRID 1450640 の反応式
[CH3:1][O:2][C:3]1C=CC(C=NO)=[CH:5][CH:4]=1.[Cl:12][N:13]1[C:17](=[O:18])[CH2:16][CH2:15][C:14]1=O.O>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:16]([C:17]([NH:13][Cl:12])=[O:18])=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 94712N-[(4-Methoxyphenyl)methylidene]hydroxylamine

生成物 1

HCID 21579386N-Chloro-4-methoxybenzamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Dissolved in 65 ml of dimethylformamide were 6.5 g (43 mmol) of 4 -methoxybenzaldoxime, followed by the gradual addition of 6.3 g (47 mmol) of N-chlorosuccinimide at room temperature. After the resultant mixture was stirred for 3 hours, 300 ml of water were added to the reaction mixture. The mixture thus formed was extracted with ethyl ether. The ether layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was distilled off, whereby 4-methoxybenzhydroxamic acid chloride was obtained.

後処理

  1. customThe mixture thus formed
  2. extractionwas extracted with ethyl ether
  3. washThe ether layer was washed with saturated saline
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-aa38c33726504debb3a09f7882b2b56d
出典データセット
uspto-grants-1997_02
特許番号
US05602160

反応ノート

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