Hydrochloric Acid → 7-Amino-3-(4-chlorophenyl)-8-hydroxy-2-isopropyl-chromen-4-one

HRID 14510ノート

反応式

HRID 14510 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13](=[O:14])[C:12]3[CH:15]=[CH:16][C:17]4[N:18]=C(C)[O:20][C:21]=4[C:11]=3[O:10][C:9]=2[CH:23]([CH3:25])[CH3:24])=[CH:4][CH:3]=1.Cl>CO>[NH2:18][C:17]1[C:21]([OH:20])=[C:11]2[C:12]([C:13](=[O:14])[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)=[C:9]([CH:23]([CH3:24])[CH3:25])[O:10]2)=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 687030987-(4-Chlorophenyl)-8-isopropyl-2-methyl-chromeno[7,8-d]oxazol-6-one

生成物 1

HCID 687013867-Amino-3-(4-chlorophenyl)-8-hydroxy-2-isopropyl-chromen-4-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

To a suspension of 7-(4-chlorophenyl)-8-isopropyl-2-methyl-chromeno[7,8-d]oxazol-6-one (650 mg, 1.84 mmol) in methanol (30 ml) is added concentrated HCl (5 ml). The reaction mixture is stirred at 70° C. for 1 h. The solvent is removed in vacuo, and the product is partitioned between CH2Cl2 and a saturated solution of NaHCO3. The organic phase is washed with water and brine, dried (MgSO4) and concentrated in vacuo to give the title compound as a pale yellow solid.

後処理

  1. customThe solvent is removed in vacuo
  2. customthe product is partitioned between CH2Cl2
  3. washThe organic phase is washed with water and brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-d0ce4eb92472410f843048d257b3e744
出典データセット
uspto-grants-2010_06
特許番号
US07732435B2

反応ノート

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