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Ethanol → 9-(1H-imidazol-1-yl)methyl-4-[(2-phenylethyl)amino]imidazo[5,1-h]pteridin-6(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | N-Benzylphenethylamine | HCID 65055 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 2-(1H-imidazol-1-ylmethyl)-1H-imidazole | HCID 19358846 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | 9-(1H-imidazol-1-yl)methyl-4-[(2-phenylethyl)amino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 9908192 | — |
反応手順
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-benzylphenylethylamine, followed by reaction with 2-(1H-imidazol-1-yl)methylimidazole, reduction with tin (II) chloride, cyclization with carbonyldiimidazole, and hydrogenation with palladium on carbon in ethanol containing 1.1 eq. NaOH at 50 psi and 50° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05602252 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-6e6a3bbd5b344200b0d3ad5ef5439664 |
| 出典メモ | uspto-grants-1997_02 |