Water → 4-(Acetamidomethyl)benzoic acid
反応式
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[C:12]([O-])(=[O:14])[CH3:13].[Na+].O>C(O)(=O)C>[C:12]([NH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=1)(=[O:14])[CH3:13]参加物
5
実験手順
A mixture of 4-aminomethylbenzoic acid (Aldrich, 1.51 g, 0.01 mol) and anhydrous sodium acetate (1.5 g, 0.018 mol) in glacial acetic acid (5 mL) was heated at reflux for 18 h. On cooling, the mixture was poured into cold water (50 mL). The precipitate was separated by filtration and washed several times with cold water. The cake was recrystallized from water to give 1.4 g (72.5%) of the title compound as a white powder, mp 195° C.
後処理
- temperaturewas heated
- temperatureat reflux for 18 h
- temperatureOn cooling
- customThe precipitate was separated by filtration
- washwashed several times with cold water
- customThe cake was recrystallized from water
出典と根拠
- ORDレコード
- ord-12f1e27cae5b4c7a9f2621ee04a97023
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05602277
反応ノート
読み込み中…