HCID 85272219、化合物 → HCID 85247288、化合物

HRID 1451107ノート

反応式

HRID 1451107 の反応式
[OH:1][N:2]=[CH:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]>C(O)C.[Pt]=O>[NH2:14][C:12]1[CH:11]=[C:6]([CH:5]=[C:4]([CH:3]=[N:2][OH:1])[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]

参加物

4

反応物 1

HCID 85272219HCID 85272219、化合物

生成物 1

HCID 85247288HCID 85247288、化合物収率 64%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

A mixture of methyl 3-[(N-hydroxylimino)methyl]-5-nitrobenzoate (2.0 g, 0.009 mol) in ethanol (150 mL) was hydrogenated in the presence of platinum oxide (0.25 g) at 30 psi for 0.5 h. The catalyst was removed by filtration through Celite and the filtrate was concentrated. The residue was recrystallized from ethyl acetate-hexane to give 1.1 g (64%) of methyl 3-amino-5-[(N-hydroxylimino)methyl]benzoate as an off-white solid, mp 160°-162° C.

後処理

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue was recrystallized from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-72bab7d9f7594470b501cc4b41296762
出典データセット
uspto-grants-1997_02
特許番号
US05602277

反応ノート

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