Diethyl Ether → Di-3-pyridinylmethanone

To a solution of 3-bromopyridine (9.84 g,0.062 mol) in 300 ml of ether cooled to -78° C. was added n-butyllithium (1.6M, 41 ml, 0.066 mol) and stirred for 30 min. N-Methyl,N-methoxy-urethane (3.76 g, 0.028 mol) in 20 ml of ether was added in 10 min, the mixture was stirred (-78° C.) for 1 h, allowed to warm to room temperature and stirred for 2 h. The reaction mixture was quenched with 6N HCl (100 ml) and stirred. The aqueous layer was basified with 10% NaOH solution, extracted with ethyl acetate (2×) and methylene dichloride. The organic layer was dried over sodium sulfate, concentrated in vacuo, and the residue was purified by chromatography on silica (ethyl acetate, 10% methanol/ethyl acetate) to afford 1,7 g (33%) of di-(3-pyridyl)ketone.

1. stirringthe mixture was stirred (-78° C.) for 1 h
2. stirringstirred for 2 h
3. customThe reaction mixture was quenched with 6N HCl (100 ml)
4. stirringstirred
5. extractionextracted with ethyl acetate (2×) and methylene dichloride
6. dry with materialThe organic layer was dried over sodium sulfate
7. concentrationconcentrated in vacuo
8. customthe residue was purified by chromatography on silica (ethyl acetate, 10% methanol/ethyl acetate)

ORDレコード

ord-f5ddc0c1f9244b348d7959c28e5a8ef7

出典データセット

uspto-grants-1997_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05604224