Triethylamine → HCID 54069381、化合物

HRID 1451784ノート

反応式

HRID 1451784 の反応式
C(N(CC)CC)C.[NH2:8][CH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:19]3[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=3)[CH:16]=2)[CH2:11]1.Br.[CH2:27]([N:30]=[C:31]=[O:32])[CH:28]=[CH2:29]>COCCO>[CH2:27]([NH:30][C:31]([NH:8][CH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:19]3[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=3)[CH:16]=2)[CH2:11]1)=[O:32])[CH:28]=[CH2:29]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 15123Allyl isocyanateHCID 214762912-aminomethyl-5-[pyridazin-3(2H)-on-6-yl]indane hydrobromide

生成物 1

HCID 54069381HCID 54069381、化合物収率 86.5%

試薬・触媒・溶媒 1

HCID 80192-Methoxyethanol溶媒

実験手順

Triethylamine (1.05 g) was added to 40 ml of a suspension containing 2.70 g of 2-aminomethyl-5-[pyridazin-3(2H)-on-6-yl]indane·hydrobromide suspended in 2-methoxyethanol, and the mixture was stirred at room temperature for 10 minutes. To the mixture was added 1.10 g of allyl isocyanate, and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and crystals precipitated were collected by filtration. The crystals obtained were washed with water, dried and then recrystallized from methanol to obtain 2.35 g of 2-[(ALLYLCARBAMOYL) amino]methyl-5-[pyridazin-3(2H)-on-6-yl]indane.

後処理

  1. stirringthe resulting mixture was stirred at room temperature for 1.5 hours
  2. customprecipitated
  3. filtrationwere collected by filtration
  4. customThe crystals obtained
  5. washwere washed with water
  6. customdried
  7. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-52d0bc0e0745418caaff364033ff91f2
出典データセット
uspto-grants-1997_02
特許番号
US05605901

反応ノート

読み込み中…