Hydrochloric Acid → HCID 19973183、化合物
反応式
CC([N:5]([CH2:9][C:10](=[O:17])[NH:11][N:12]1[CH:16]=[CH:15][CH:14]=[CH:13]1)C(=O)[O-])(C)C.[ClH:18]>>[ClH:18].[NH2:5][CH2:9][C:10]([NH:11][N:12]1[CH:16]=[CH:15][CH:14]=[CH:13]1)=[O:17]参加物
3
実験手順
To 1,1-dimethylethyl-[2-oxo-2-(1H-pyrrol-1-ylamino)ethyl]carbamate (5.67 g) was added 35 ml of a 3.7M ethereal hydrogen chloride solution. The reaction mixture was stirred at room temperature over a period of 5 hours. The colored powder obtained by suction filtration was purified by addition of a solution of the product in methanol/diethyl ether, collecting the precipitate and repeating this procedure several times until the greater part of the substance was dissolved in the mother liquors. The last precipitate was discarded and the combined mother liquors were again recrystallized from methanol/diethyl ether. This afforded 1.90 g (46%) of the product as a powder, m.p. 212°-215° C. (dec.).
後処理
- customThe colored powder obtained by suction filtration
- customwas purified by addition of a solution of the product in methanol/diethyl ether
- customcollecting the precipitate
- dissolutionwas dissolved in the mother liquors
- customthe combined mother liquors were again recrystallized from methanol/diethyl ether
出典と根拠
- ORDレコード
- ord-c153fb3b902741c584213ecf4d9da54e
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05605925
反応ノート
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