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Acetone → Benzo[1,3]dioxole-2,2-dicarboxylic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diethyl bromomalonate | HCID 69637 | — |
| 反応物 | 2-Oxazolidinone | HCID 73949 | — |
| 生成物 | Benzo[1,3]dioxole-2,2-dicarboxylic acid diethyl ester | HCID 12969876 | — |
反応手順
A mixture of 0.240 g of the above oxazolidinone, 0.250 g of diethylbromomalonate, 0.500 g of anhydrous potassium carbonate and 10 ml of acetone is stirred overnight, filtered, washed with acetone and evaporated to a brown oil. The oil is purified by flash chromatography, eluting with 5% acetone/toluene. The pure fractions are combined and evaporated giving (S,R)-5-(1-naphthyloxymethyl)-2-oxo-3-oxazolidinyl)propyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05606069 |
| 出典データセット | uspto-grants-1997_02 |
| ORD ID | ord-4e8b0a2bc98544b3b014761d8d87e044 |
| 出典メモ | uspto-grants-1997_02 |