3-Methylpiperidine → 5-Fluoro-4-(3-methylpiperidino)-6-(2-pentynyloxy)pyrimidine
反応式
Cl[C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])[N:5]=[CH:4][N:3]=1.[CH3:15][CH:16]1[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]1>>[F:8][C:7]1[C:2]([N:18]2[CH2:19][CH2:20][CH2:21][CH:16]([CH3:15])[CH2:17]2)=[N:3][CH:4]=[N:5][C:6]=1[O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14]参加物
3
実験手順
0.2 g of 4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine and 0.29 g of 3-methylpiperidine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.23 g of 5-fluoro-4-(3-methylpiperidino)-6-(2-pentynyloxy)pyrimidine (hereinafter, referred to as Compound (10)).
出典と根拠
- ORDレコード
- ord-9d3ca9406e9a45a58b25a3f372c9a735
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732448B2
反応ノート
読み込み中…