Benzylamine → N-[(benzylamino)carbonyl]-2-methylacrylamide

HRID 1452125

反応式

HRID 1452125 の反応式
[C:1]([NH:6][C:7](=[O:11])OCC)(=[O:5])[C:2]([CH3:4])=[CH2:3].[CH2:12]([NH2:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[CH2:12]([NH:19][C:7]([NH:6][C:1](=[O:5])[C:2]([CH3:4])=[CH2:3])=[O:11])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 13628540Ethyl (2-methylacryloyl)carbamate

生成物 1

HCID 639951N-[(benzylamino)carbonyl]-2-methylacrylamide収率 42.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

A reaction vessel was charged with 78.5 g of ethyl N-methacryloylcarbamate and 53.5 g of benzylamine to which 100 g of toluene were added and heated at 100° C. for 30 minutes, The resulting mixture was condensed under reduced pressure and isolated by column chromatography to obtain 46.4 g of N-benzyl-N'-methacryloyl urea having a melting point of 96°-98° C.

後処理

  1. additionwere added
  2. customcondensed under reduced pressure
  3. customisolated by column chromatography

出典と根拠

ORDレコード
ord-a8d45f9f89c844ebb793f09535acb143
出典データセット
uspto-grants-1997_02
特許番号
US05606096

関連ノート

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