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Furfurylamine → 4-[1-(4-Cyano-3-trifluoromethyl-phenoxymethyl)-2,2-dimethyl-cyclopropoxy]-2-trifluoromethyl-benzonitrile

HRID 1452611
ノート
印刷プレビュー

反応式

HRID 1452611 の反応式
[C:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][CH:8]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:9]([OH:11])=O)=[CH:5][C:4]=1[C:18]([F:21])([F:20])[F:19])#[N:2].[CH:22]1[CH:23]=[CH:24][C:25]2N(O)N=N[C:26]=2[CH:27]=1.O1C=CC=C1[CH2:37][NH2:38].N=C=N>CN(C=O)C>[C:37]([C:25]1[CH:24]=[CH:23][C:22]([O:11][CH2:9][C:8]2([O:7][C:6]3[CH:16]=[CH:17][C:3]([C:1]#[N:2])=[C:4]([C:18]([F:21])([F:20])[F:19])[CH:5]=3)[CH2:12][C:13]2([CH3:15])[CH3:14])=[CH:27][C:26]=1[C:18]([F:21])([F:20])[F:19])#[N:38]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 3438FurfurylamineHCID 757711-HydroxybenzotriazoleHCID 160435CarbodiimideHCID 575985402-(4-Cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid

生成物 1

HCID 115542704-[1-(4-Cyano-3-trifluoromethyl-phenoxymethyl)-2,2-dimethyl-cyclopropoxy]-2-trifluoromethyl-benzonitrile

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒
2 回

反応条件

温度
70 °C

実験手順

To 1 mL of 0.1M(molar) solutions of the 2-(4-Cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid in DMF(dimethylformamide) (0.1 mmol) were added 0.5 mL of a 0.376M solution of HOBT, 1-hydroxybenztriaole, (0.2 mmol) in DMF, 0.1 mL of a 0.1M solution of the C-furan-2-yl-methylamine (0.1 mmol) in DMF, and approximately 183 mg of silica bound carbodiimide (loading: 1.09 g/mmol, 0.2 mmol). The resultant mixtures were shaken and heated at 70° C. for approximately 18 h. The reactions were filtered and the resin thoroughly rinsed with DMF. The solvent was removed in-vacuo to obtain oils that were then purified by HPLC(high performance liquid chromatography).

後処理

  1. filtrationThe reactions were filtered
  2. washthe resin thoroughly rinsed with DMF
  3. customThe solvent was removed in-vacuo
  4. customto obtain oils that
  5. customwere then purified by HPLC(high performance liquid chromatography)

出典と根拠

ORDレコード
ord-e72024fd52bb4220b3db60fc39bcd234
出典データセット
uspto-grants-2009_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07473711B2

反応ノート

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このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート