Isopropanol → (6-Allyl-5-chloropyrazolo[1,5-a]pyrimidin-7-yl)(4-ethoxyphenyl)amine

HRID 1452622ノート

反応式

HRID 1452622 の反応式
C(O)(C)C.[CH2:5]([C:8]1[C:9]([Cl:18])=[N:10][C:11]2[N:12]([N:15]=[CH:16][CH:17]=2)[C:13]=1Cl)[CH:6]=[CH2:7].[CH3:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=1>C(N(CC)CC)C>[CH2:5]([C:8]1[C:9]([Cl:18])=[N:10][C:11]2[N:12]([N:15]=[CH:16][CH:17]=2)[C:13]=1[NH:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][CH2:20][CH3:19])=[CH:23][CH:24]=1)[CH:6]=[CH2:7]

参加物

5

反応物 3

HCID 3776IsopropanolHCID 90764-EthoxyanilineHCID 575268456-Allyl-5,7-dichloropyrazolo[1,5-a]pyrimidine

生成物 1

HCID 57526813(6-Allyl-5-chloropyrazolo[1,5-a]pyrimidin-7-yl)(4-ethoxyphenyl)amine収率 100%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
40 °C

実験手順

To an isopropanol (52 mL) solution containing 6-allyl-5,7-dichloropyrazolo[1,5-a]pyrimidine (5.98 g), triethylamine (12.7 mL) and phenethidine (4.30 g) were added, and this mixture was stirred at 40° C. for 5 hr. After the reaction, the solvent was distilled off. Saturated aqueous sodium hydrogen carbonate was added to the residue, and the mixture was extracted with ethyl acetate. The combined ethyl acetate layer was dried over sodium sulfate. After the sodium sulfate was filtered off, the filtrate was concentrated to obtain the title compound (8.62 g).

後処理

  1. additionwere added
  2. customAfter the reaction
  3. distillationthe solvent was distilled off
  4. additionSaturated aqueous sodium hydrogen carbonate was added to the residue
  5. extractionthe mixture was extracted with ethyl acetate
  6. dry with materialThe combined ethyl acetate layer was dried over sodium sulfate
  7. filtrationAfter the sodium sulfate was filtered off
  8. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-f59e88fd31274ea4be9ce626c26fb574
出典データセット
uspto-grants-2009_01
特許番号
US07473694B2

反応ノート

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