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Tetrahydrofuran → N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2-Methanesulfonylbenzene-1-sulfonyl chloride | HCID 2735178 | — |
| 反応物 | tert-Butyl 5-amino-3-methyl-1H-indazole-1-carboxylate | HCID 59276571 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide | HCID 22567145 | 88.5% |
反応手順
N-(N-tert-Butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide can be obtained as described in Example 1 from 0.9 g of 5-amino-N-tert-butoxycarbonyl-3-methyl-1H-indazole, 55 ml of tetrahydrofuran, 1 ml of triethylamine and 1.02 g of 2-methylsulfonylbenzenesulfonyl chloride. 1.5 g of N-(N-tert-butoxycarbonyl-3-methyl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide are thus obtained in the form of a pink solid melting at 228° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07473701B2 |
| 出典データセット | uspto-grants-2009_01 |
| ORD ID | ord-5494c8915a954c9bbac163b619dc8728 |
| 出典メモ | uspto-grants-2009_01 |