関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | (2-Aminobenzothiazol-6-yl)acetic acid | HCID 757163 | — |
| 反応物 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Methyl 2-(2-aminobenzo[d]thiazol-6-yl)acetate | HCID 45077305 | 81% |
反応手順
A mixture of 2-(2-aminobenzo[d]thiazol-6-yl)acetic acid (95%, 10.0 g, 45.6 mmol), methanol (50 mL), 4 N HCl/1,4-dioxane (12.0 mL, 48.0 mmol) in 1,4-dioxane (30 mL) was heated at 75° C. for 9 hr and then concentrated under vacuum. The residue was suspended into water (50 mL) and basified to pH 9 with 1N NaOH solution. The title compound (8.19 g, 81% yield) was collected as a pale solid by suction filtration and dried under vacuum at 50° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07473784B2 |
|---|
| 出典データセット | uspto-grants-2009_01 |
|---|
| ORD ID | ord-2a65b4fc401246b08a268238481bcabf |
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| 出典メモ | uspto-grants-2009_01 |
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