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2-Ethylpiperidine → 4-(2-Butynyloxy)-6-(2-ethylpiperidino)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Ethylpiperidine | HCID 94205 | — |
| 反応物 | 4-(2-Butynyloxy)-6-chloropyrimidine | HCID 12137602 | — |
| 生成物 | 4-(2-Butynyloxy)-6-(2-ethylpiperidino)pyrimidine | HCID 59341136 | 32.9% |
反応手順
0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.56 g of 2-ethylpiperidine were mixed and left for 18 hours at 80° C. The reaction mixture was cooled to near room temperature and subjected to silica gel column chromatography to obtain 0.14 g of 4-(2-butynyloxy)-6-(2-ethylpiperidino)pyrimidine (hereinafter, referred to as Compound (22)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732448B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-04ef764e85d64f98abad7fe047736f5c |
| 出典メモ | uspto-grants-2010_06 |