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4-(1H-1,2,4-triazol-1-yl)benzaldehyde → 6-[2-(3-Chloro-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-4-hydroxy-3-(4-[1,2,4]triazol-1-yl-benzyl)-5,6-dihydro-pyran-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(1H-1,2,4-triazol-1-yl)benzaldehyde | HCID 2776488 | — |
| 反応物 | 6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-dihydro-3H-pyran-2,4-dione | HCID 16076109 | — |
| 生成物 | 6-[2-(3-Chloro-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-4-hydroxy-3-(4-[1,2,4]triazol-1-yl-benzyl)-5,6-dihydro-pyran-2-one | HCID 58762271 | — |
反応手順
The title compound was prepared by coupling 6-[2-(3-Chloro-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-dihydro-pyran-2,4-dione from Step 1 of Example B(13), to 4-[1,2,4]Triazol-1-yl-benzaldehyde using the Me2NHBH3 method described in the synthesis of Example B(31). ESIMS (MH+): 509.1
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07473790B2 |
| 出典データセット | uspto-grants-2009_01 |
| ORD ID | ord-6b19367acc0d48ae87cb37a7c33eadce |
| 出典メモ | uspto-grants-2009_01 |