Boron tribromide → 2-(2-Fluoro-4-hydroxyphenyl)-2-methylpropanenitrile

HRID 1453306ノート

反応式

HRID 1453306 の反応式
[F:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[CH:4][C:3]=1[C:10]([CH3:14])([CH3:13])[C:11]#[N:12].B(Br)(Br)Br>C(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:10]([CH3:14])([CH3:13])[C:11]#[N:12]

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 450914982-(2-Fluoro-4-methoxyphenyl)-2-methylpropanenitrile

生成物 1

HCID 601250122-(2-Fluoro-4-hydroxyphenyl)-2-methylpropanenitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-(2-Fluoro-4-methoxy-phenyl)-2-methyl-propionitrile (1.5 g, 7.8 mmol) in CH2Cl2 (75 mL) at −78° C. was added Boron tribromide (1M solution in CH2Cl2) (16 mL, 16 mmol). The solution was allowed to warm to room temperature and stir for 48 hours. The reaction was quenched with 0.5N HCl (50 mL) and poured into water (100 mL). The organic layer was separated and the aqueous was extracted with CH2Cl2 (50 mL). The combined organics were washed with water (100 mL), dried over Na2SO4, filtered and concentrated. The resulting oil was used without further purification.

後処理

  1. customThe reaction was quenched with 0.5N HCl (50 mL)
  2. additionpoured into water (100 mL)
  3. customThe organic layer was separated
  4. extractionthe aqueous was extracted with CH2Cl2 (50 mL)
  5. washThe combined organics were washed with water (100 mL)
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe resulting oil was used without further purification

出典と根拠

ORDレコード
ord-7419275967ab428782b28ff006e0ba7a
出典データセット
uspto-grants-2009_01
特許番号
US07473790B2

反応ノート

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