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Water → 2-bromo-3-(2-butyn-1-yl)-5-(trans-2-methoxy-vinyl)-3H-imidazole-4-carboxylic acid-(3-methyl-isoquinolin-1-ylmethyl)-amide

HRID 1453546
ノート
印刷プレビュー

反応式

HRID 1453546 の反応式
[Br:1][C:2]1[NH:6][C:5]([C:7]([OH:9])=O)=[C:4](/[CH:10]=[CH:11]/[O:12][CH3:13])[N:3]=1.CN(C(ON1N=N[C:24]2[CH:25]=CC=[CH:28][C:23]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:36][C:37]1[N:38]=[C:39]([CH2:47][NH2:48])[C:40]2[C:45]([CH:46]=1)=[CH:44][CH:43]=[CH:42][CH:41]=2.O>C(N(CC)CC)C.CN(C)C=O>[CH3:36][C:37]1[N:38]=[C:39]([CH2:47][NH:48][C:7]([C:5]2[N:6]([CH2:28][C:23]#[C:24][CH3:25])[C:2]([Br:1])=[N:3][C:4]=2/[CH:10]=[CH:11]/[O:12][CH3:13])=[O:9])[C:40]2[C:45]([CH:46]=1)=[CH:44][CH:43]=[CH:42][CH:41]=2
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 962WaterHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 215066303-Methyl-isoquinolin-1-ylmethylamineHCID 178494817HCID 178494817、化合物

生成物 1

HCID 689749602-bromo-3-(2-butyn-1-yl)-5-(trans-2-methoxy-vinyl)-3H-imidazole-4-carboxylic acid-(3-methyl-isoquinolin-1-ylmethyl)-amide

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒
HCID 8471Triethylamine溶媒

実験手順

A solution of 3.50 g 2-bromo-5-(trans-2-methoxy-vinyl)-3H-imidazole-4-carboxylic acid and 1.30 g TBTU in 1.20 ml triethylamine and 30 ml of dimethylformamide is stirred for 15 min at ambient temperature. Then 1.09 g 3-methyl-isoquinolin-1-ylmethylamine are added, and the resulting suspension is stirred for 4 h at ambient temperature. Then ice-cooled water is added and the precipitate is separated off. The precipitate is dissolved in dichloromethane, the solution is dried over sodium sulphate and the solvent is removed.

後処理

  1. additionis added
  2. customthe precipitate is separated off
  3. dissolutionThe precipitate is dissolved in dichloromethane
  4. dry with materialthe solution is dried over sodium sulphate
  5. customthe solvent is removed

出典と根拠

ORDレコード
ord-10f19dfeff4a4566a862f23fdec16645
出典データセット
uspto-grants-2009_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07476671B2

反応ノート

読み込み中…

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