化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1453579作成日：2026年10月25日
Benzimidazole → 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl) ethoxy]methyl]-9H-purine
https://huagongshe.com/reaction/1453579
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzimidazole | HCID 5798 | — |
| 反応物 | Dibenzyl ether | HCID 7657 | — |
| 反応物 | 2,6-Dichloro-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine | HCID 58285232 | — |
| 反応物 | HCID 178420378 | HCID 178420378 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl) ethoxy]methyl]-9H-purine | HCID 86614102 | 48.8% |
反応手順
860 mg of product obtained in stage 1 above are mixed with 605 mg of 5-(phenylmethoxy)-1H-benzimidazole (benzyl ether in the 5-position of benzimidazole) and 15 ml of butanol. The mixture is heated at 120° C. for 24 hours. Partial drying, washing with H2O and then drying under vacuum at 50° C. are carried out. 667 mg of 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl)ethoxy]methyl]-9H-purine are obtained, in the form of beige-colored crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07476670B2 |
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| 出典データセット | uspto-grants-2009_01 |
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| ORD ID | ord-f128de6f5f6748459fc36bcee54d9c29 |
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| 出典メモ | uspto-grants-2009_01 |
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