1-(3-Bromophenyl)-2-(methylamino)ethan-1-ol → HCID 178499182、化合物

HRID 1453887ノート

反応式

HRID 1453887 の反応式
[CH2:1]([O:8][C:9]1[C:10]([C:18]([OH:20])=O)=[N:11][NH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:21][C:22]1[CH:23]=[C:24]([CH:28]([OH:32])[CH2:29][NH:30][CH3:31])[CH:25]=[CH:26][CH:27]=1>>[CH2:1]([O:8][C:9]1[C:13]([C:14]([O:16][CH3:17])=[O:15])=[N:12][NH:11][C:10]=1[C:18]([N:30]([CH2:29][CH:28]([C:24]1[CH:25]=[CH:26][CH:27]=[C:22]([Br:21])[CH:23]=1)[OH:32])[CH3:31])=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 219434511-(3-Bromophenyl)-2-(methylamino)ethan-1-olHCID 57528495Methyl 4-benzyloxy-3-carboxy-1H-pyrazole-5-carboxylate

生成物 1

HCID 178499182HCID 178499182、化合物

実験手順

The title compound was prepared from methyl 4-benzyloxy-3-carboxy-1H-pyrazole-5-carboxylate (prepared as in Example 31, Step 1) using a procedure similar to that described in Example 31, Step 2, except that 1-(3-bromophenyl)-2-(methylamino)ethanol (prepared as described in Tsushima, S., et al., EP 278621 and Cudahy, M. M., et al., WO 2003059911) was used in place of (1R)-2-(methylamino)-1-phenylethanol. ES MS (M+2)=490.

出典と根拠

ORDレコード
ord-6a1ae8634c3341b5ac75078a74c2853c
出典データセット
uspto-grants-2009_01
特許番号
US07476666B2

反応ノート

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