4-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester → Tert-butyl 4-amino-2-methylpyrrolidine-1-carboxylate

HRID 1454264ノート

反応式

HRID 1454264 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([N:13]=[N+]=[N-])[CH2:10][CH:9]1[CH3:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(OC(=O)C)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([NH2:13])[CH2:10][CH:9]1[CH3:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 1

HCID 140411954-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester

生成物 1

HCID 19354295Tert-butyl 4-amino-2-methylpyrrolidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The 4-azido-2-methyl-pyrrolidine-1-carboxylic acid t-butyl ester (93.41 mg, 0.41 mmol) was taken up in ethyl-acetate in a Paar vessel. The solution was flushed with argon and Pd/C (100.00 mg) was added to the vessel. The argon atmosphere was replaced by hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen atmosphere was replaced by argon and the solution was filtered through a celite pad. The pad was washed twice with ethyl acetate. The solvent was removed under reduced pressure. The product was used without further purification. Yield 79.65 mg.C10H20N2O2 MS m/e=200.2 (M+).

後処理

  1. customThe solution was flushed with argon and Pd/C (100.00 mg)
  2. additionwas added to the vessel
  3. filtrationthe solution was filtered through a celite pad
  4. washThe pad was washed twice with ethyl acetate
  5. customThe solvent was removed under reduced pressure
  6. customThe product was used without further purification

出典と根拠

ORDレコード
ord-b020f155c70b428d9f29ab9eba860fc9
出典データセット
uspto-grants-2009_01
特許番号
US07479495B2

反応ノート

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